Objectives: There is considerable actual and potential waste in research. Evidence-based research ensures worthwhile and valuable research. The aim of this series, which this article introduces, is to describe the evidence-based research approach.
Study design and setting: In this first article of a three-article series, we introduce the evidence-based research approach. Evidence-based research is the use of prior research in a systematic and transparent way to inform a new study so that it is answering questions that matter in a valid, efficient, and accessible manner.
Results: We describe evidence-based research and provide an overview of the approach of systematically and transparently using previous research before starting a new study to justify and design the new study (article #2 in series) and-on study completion-place its results in the context with what is already known (article #3 in series).
Conclusion: This series introduces evidence-based research as an approach to minimize unnecessary and irrelevant clinical health research that is unscientific, wasteful, and unethical.
Keywords: Clinical health research; Clinical trials; Evidence synthesis; Evidence-based research; Medical ethics; Research ethics; Systematic review.
Copyright © 2020 Elsevier Inc. All rights reserved.
Lund H, Juhl CB, Nørgaard B, Draborg E, Henriksen M, Andreasen J, Christensen R, Nasser M, Ciliska D, Clarke M, Tugwell P, Martin J, Blaine C, Brunnhuber K, Robinson KA; Evidence-Based Research Network. Lund H, et al. J Clin Epidemiol. 2021 Jan;129:158-166. doi: 10.1016/j.jclinepi.2020.07.019. Epub 2020 Sep 26. J Clin Epidemiol. 2021. PMID: 32987159
Lund H, Juhl CB, Nørgaard B, Draborg E, Henriksen M, Andreasen J, Christensen R, Nasser M, Ciliska D, Tugwell P, Clarke M, Blaine C, Martin J, Ban JW, Brunnhuber K, Robinson KA; Evidence-Based Research Network. Lund H, et al. J Clin Epidemiol. 2021 Jan;129:167-171. doi: 10.1016/j.jclinepi.2020.07.021. Epub 2020 Sep 23. J Clin Epidemiol. 2021. PMID: 32979490
Lund H, Bała M, Blaine C, Brunnhuber K, Robinson KA. Lund H, et al. Pol Arch Intern Med. 2021 Sep 30;131(9):848-853. doi: 10.20452/pamw.16076. Epub 2021 Sep 30. Pol Arch Intern Med. 2021. PMID: 34590450
Schmucker C, Motschall E, Antes G, Meerpohl JJ. Schmucker C, et al. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2013 Oct;56(10):1390-7. doi: 10.1007/s00103-013-1818-y. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2013. PMID: 23978984 Review. German.
Kacha AK, Nizamuddin SL, Nizamuddin J, Ramakrishna H, Shahul SS. Kacha AK, et al. J Cardiothorac Vasc Anesth. 2018 Dec;32(6):2789-2801. doi: 10.1053/j.jvca.2018.02.009. Epub 2018 Feb 7. J Cardiothorac Vasc Anesth. 2018. PMID: 29571641 Review. No abstract available.
Lozada-Martinez ID, Lozada-Martinez LM, Cabarcas-Martinez A, Ruiz-Gutierrez FK, Aristizabal Vanegas JG, Amorocho Lozada KJ, López-Álvarez LM, Fiorillo Moreno O, Navarro Quiroz E. Lozada-Martinez ID, et al. Front Genet. 2024 Jan 18;15:1327243. doi: 10.3389/fgene.2024.1327243. eCollection 2024. Front Genet. 2024. PMID: 38304339 Free PMC article.
Batista Mendoza G, Giraldo Puentes GA, Rosero Palacios E, Brett Cano PJ, Ramírez Reyes KT, Zapata Valencia CM, Suarez Uribe YL, Reyes AF, Acuña Picón-Jaimes YA. Batista Mendoza G, et al. Arch Peru Cardiol Cir Cardiovasc. 2023 Dec 27;4(4):141-150. doi: 10.47487/apcyccv.v4i4.328. eCollection 2023 Oct-Dec. Arch Peru Cardiol Cir Cardiovasc. 2023. PMID: 38298417 Free PMC article. Spanish.
Rosen D, Reiter NL, Vogel B, Prill R. Rosen D, et al. Syst Rev. 2024 Jan 13;13(1):28. doi: 10.1186/s13643-023-02427-7. Syst Rev. 2024. PMID: 38216987 Free PMC article.
Hu XY, Tian ZY, Chen H, Hu XY, Ming TY, Peng HX, Jiao RM, Shi LJ, Xiu WC, Yang JW, Gang WJ, Jing XH. Hu XY, et al. Chin J Integr Med. 2024 Jun;30(6):551-558. doi: 10.1007/s11655-023-3711-3. Epub 2023 Nov 21. Chin J Integr Med. 2024. PMID: 37987960
Yu X, Wu S, Sun Y, Wang P, Wang L, Su R, Zhao J, Fadlallah R, Boeira L, Oliver S, Abraha YG, Sewankambo NK, El-Jardali F, Norris SL, Chen Y. Yu X, et al. BMJ Evid Based Med. 2024 Jan 19;29(1):37-43. doi: 10.1136/bmjebm-2023-112355. BMJ Evid Based Med. 2024. PMID: 37940419 Free PMC article.